Personal Genome

Novel gene abnormalities discovered in a subpopulation of lung and colorectal tumors could potentially identify patients with a good chance of responding to highly specific “targeted” drugs already in use for treating other cancers, scientists report. The genetic alterations – pieces of two genes fused together - showed up in a massive search of the DNA in s […]

Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people. Their findings provide new ways to predict and personalize the diagnosis and treatment […]

Genes that are known to be involved in inflammation were found to be related to risk of ovarian cancer. […]

Researchers have produced liver-like cells from induced pluripotent stem cells. By creating liver-like cells, scientists can study why people respond differently to Hepatitis C. […]

Using a liquid laser, researchers have developed a better way to detect the slight genetic mutations that might predispose a person to a particular type of cancer or other diseases. […]

Scientists have made a major genetic breakthrough that could change the way pediatric cancers are treated in the future. The researchers identified two genetic mutations responsible for up to 40 per cent of glioblastomas in children. The mutations were found to be involved in DNA regulation, which could explain the resistance to traditional treatments, and m […]

Among women with invasive epithelial ovarian cancer, patients having a germline (gene change in a reproductive cell that could be passed to offspring) mutation in the BRCA1 or BRCA2 genes was associated with improved five-year overall survival, with BRCA2 carriers having the best prognosis, according to a new study. […]

Smokers are more likely to have molecular features of cancerization in the large airway epithelium. Smokers with COPD had significant changes in the small airway epithelium, new research has shown. New findings could lead to development of a diagnostic test. […]

Novel Hsp90 inhibitor shows activity in slowing KRAS-mutant NSCLC tumor cell growth. Use with traditional chemotherapy resulted in increased cancer cell death. Phase 2b/3 trial combined with docetaxel underway. […]

To address the prospects for personalized medicine in diabetes, investigators have surveyed the field for existing research. […]