Toward personalized medicine in renal transplantation.

Toward personalized medicine in renal transplantation.

Transplant Proc. 2010 Oct;42(8):2864-7

Authors: Lampreabe I, Gainza de los Rios FJ, Arrieta Gutiérrez A, Jofre-Monseny L, Rodriguez M, Amenabar Iribar JJ, Zárraga Larrondo S, Tejedor D, Martinez A, Olano-Martin E

The pharmacokinetics of tacrolimus (TRL) are clearly affected by genetic polymorphisms in drug-metabolizing enzymes, which lead to large interindividual differences in dose-response relations. In addition, TRL has a narrow therapeutic index requiring monitoring of blood levels. The objective of the present observational, retrospective study was to associate maintenance TRL doses with various genetic markers seeking to guide optimization of the initial dose.

PMID: 20970553 [PubMed - in process]

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Personal Genome

Toward personalized medicine in renal transplantation.

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Personalized medicine from Sciencedaily