A recent study in The Lancet reported that variation on the Y chromosome is associated with coronary artery disease (CAD) in British men. Here, we discuss the special properties of the Y chromosome and their implications for association studies, our concerns about the evidence the authors use to support their finding, and observations from the 23andMe database for haplogroup I and heart disease.
A genetic variant in the KIF6 gene has been controversially linked to heart disease and statin response. In 2010 it looked like the tide was turning and that there was no association after all, but now new research suggests that the relationship may simply be a little more complex.
By Arnab Chowdry, Senior Scientific Software Engineer at 23andMe Having been young and healthy for the majority of my life, I haven’t had many opportunities to interact with our health care system. Not too long ago I was a sedentary, slightly-overweight, South Asian man entering my thirties. I had some ambiguous family history of diabetes [...]
The personal genome and the practice of cardiovascular medicine.
Methodist Debakey Cardiovasc J. 2010 Nov;6(4):13-20
Authors: Marian AJ
Recent advances in the DNA sequencing techniques have made it possible to sequen…
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